Epigenetic’s Science is composed by award winning writer, Raoul Pedretta. Great bye, genetically encoded genes… the first book in the exciting new field of epigenetic biology for general readers. The surging new science of epigenetic genetics provides a veritable cornucopia of new insights into our own bodies and minds – some unsettling, some comforting. The premise of Epigenetic’s Science is that environmental exposures can have long lasting effects on cellular function. Some of these effects are not very easy to reverse and the authors describe how”epigenetic inheritance” can result in such disorders as cancer, Alzheimer’s disease and Parkinson’s. They also clarify the surprising effect of”epigenetic pollution,” environmental contaminants that aren’t detected by standard testing and that could cause severe health problems.
Like all living systems, cells are constantly changing and grow, divide and die. All cells need a continuous supply of energy, and this process is initiated by a process referred to as”mimetic induction”. Through natural selection, positive mutations accumulate over generations, and if they get together, these cells form a sort of cellular memory, or methylation state. This methylation state is passed between generations and decides how cells in 1 family will act in response to environmental challenges and how those cells will respond when similar challenges arise in another family member.
When methylation is induced in a cell, the result may be a whole gamut of changes on the cell surface and in the biochemical pathways inside the cell. This results in alterations in gene function and a corresponding response physically. There are many ways in which Epigenetic’s Science presents the science of Epigenetics. For example, each chapter contains an informative section addressing one of the most common Epigenetic changes which exist in all people: puberty. The chapters comprise;”Growthal Sensitivity,””Mutations at Birth,”” hormonal changes,””perinatal development,””adolescent-onset diabetes,” and”nutrition.” I enjoyed each of these and found them to be quite interesting and educational.
As you know, during adolescence, the body increases its production of estrogen (in anticipation of future pregnancy), and then, produces DHT (which stands for”dihydrotestosterone”). DHT subsequently binds to the hair follicles, making it difficult for nutrients to reach the roots. This causes baldness in a condition called”male pattern baldness.” Interestingly, this isn’t the only cause of hair loss, as there are other genetic and environmental factors that contribute to hair loss. Epigenetic science goes a step further and suggests that these other causes of hair loss may also be affected by methylation, so future study might shed more light on Epigenetic’s Science.
The next topic that Epigenetic’s Science touches on is the effect that diet has on the body. In particular, Epigenetic’s Science goes into detail about the impact that diet has on rats, rodents, and other organisms. To start with, one interesting finding was that when the worm C. elegans was given a high fat diet, it became diabetic and obese. Interestingly, the laboratory animals also lost muscle mass, which is suggestive of insulin resistance. In another experiment, the laboratory animals were put on a special type of diet where they only received food which contained carbohydrates; they lost body weight fairly quickly.
In order to understand what is going on here, you must take a look at the Epigenetic’s Science methodology. Basically, they’re growing yeast in laboratory cultures and watching what happens. After the yeast grows to a certain point, it is going to replicate and thus create a new production of yeast cells. In this case, the generation of cells was used to study insulin resistance, something that we humans have.
Of course, there are additional Epigenetic’s Science techniques that they use, including gene regulation and the study of cancerous tumors. In actuality, they have recently established a successful clinical trial where they are attempting to treat Alzheimer’s disease in mice. As exciting as that may sound, it is not your everyday normal cancer therapy. This study shows they are able to control and regulate cells and halt the growth of cancerous tumors.
Besides diabetes, Epigenetic’s Science can be used for other types of diseases and conditions, such as Parkinson’s, arthritis, Multiple Sclerosis, and even cancer. Needless to say, these studies are extremely small so we don’t have much of a sense of what they will mean for human health. Still, it is an exciting and very promising prospect. Just think, one day you might be able to grow your own cells for immune system support and energy production; essentially creating your own drug factory!