Epigenetic’s Science is composed by award winning author, Raoul Pedretta. Good bye, genetically encoded genes… the first book in the exciting new field of epigenetic biology for general readers. The surging new science of epigenetic genetics provides a veritable cornucopia of fresh insights into our own bodies and minds – some unsettling, some reassuring. The premise of Epigenetic’s Science is that environmental exposures can have long lasting effects on cellular function. Some of these effects are not so easy to reverse and the authors describe how”epigenetic inheritance” can lead to such disorders as cancer, Alzheimer’s disease and Parkinson’s. They also clarify the surprising effect of”epigenetic pollution,” environmental contaminants that are not detected by standard testing and that can cause serious health issues.
Like all living systems, cells are constantly changing and grow, divide and die. All cells need a constant supply of energy, and this procedure is initiated by a process referred to as”mimetic induction”. Through natural selection, favorable mutations accumulate over generations, and if they get together, these cells form a type of cellular memory, or methylation state. This methylation state is passed on between generations and decides how cells in 1 family will act in response to environmental challenges and how those cells will react when similar challenges arise in another household member.
When methylation is induced in a cell, the result can be a whole gamut of changes on the cell surface and in the biochemical pathways inside the cell. This causes alterations in gene function and a corresponding reaction on the body. There are many ways in which Epigenetic’s Science presents the science of Epigenetics. For instance, each chapter includes an informative section addressing one of the most frequent Epigenetic changes which exist in all of us: puberty. The chapters include;”Growthal Sensitivity,””Mutations in Birth,”” hormonal changes,””perinatal development,””adolescent-onset diabetes,” and”nutrition.” I enjoyed each of these and found them to be very interesting and educational.
As you know, during adolescence, the body increases its production of estrogen (in anticipation of future pregnancy), and in turn, produces DHT (which stands for”dihydrotestosterone”). DHT then binds to the hair follicles, making it difficult for nutrients to reach the roots. This causes baldness in a condition known as”male pattern baldness” Interestingly, this is not the only cause of hair loss, as there are other genetic and environmental factors that contribute to hair loss. Epigenetic science goes a step further and suggests that these other causes of hair loss may also be influenced by methylation, so future study might shed even more light on Epigenetic’s Science.
The next topic that Epigenetic’s Science touches on is the impact that diet has on the body. Specifically, Epigenetic’s Science goes into detail about the effect that diet has on mice, worms, and other organisms. To begin with, one interesting finding was that when the worm C. elegans has been given a high fat diet, it became diabetic and obese. Interestingly, the laboratory animals also lost muscle mass, which is suggestive of insulin resistance. In another experiment, the laboratory animals were put on a special type of diet where they just received food that contained carbohydrates; they lost body weight fairly quickly.
So as to understand what’s going on here, you have to have a look at the Epigenetic’s Science methodology. Fundamentally, they are growing yeast in laboratory cultures and watching what happens. When the yeast grows to a certain point, it is going to replicate and thus create a new generation of yeast cells. In this case, the creation of cells was used to study insulin resistance, something that we humans possess.
Of course, there are other Epigenetic’s Science techniques they use, including gene regulation and the study of cancerous tumors. In fact, they’ve recently launched a successful clinical trial where they are attempting to treat Alzheimer’s disease in mice. As exciting as that may seem, it’s not your regular normal cancer therapy. This study shows they are able to control and regulate cells and halt the growth of cancerous tumors.
Besides diabetes, Epigenetic’s Science can be used for other types of diseases and ailments, such as Parkinson’s, arthritis, Multiple Sclerosis, and even cancer. Needless to say, these studies are very small so we don’t have much of a sense of what they will mean for human health. Still, it’s an exciting and very promising prospect. Just think, one day you could have the ability to grow your own cells for immune system support and energy production; essentially creating your very own drug factory!