Epigenetic’s Science is composed by award winning author, Raoul Pedretta. Great bye, genetically encoded genes… the first book in the exciting new field of epigenetic biology for general readers. The surging new science of epigenetic genetics provides a veritable cornucopia of fresh insights into our own bodies and minds – some unsettling, some comforting. The assumption of Epigenetic’s Science is the fact that environmental exposures can have long lasting effects on cellular function. Some of these effects aren’t very easy to reverse and the authors describe how”epigenetic inheritance” can result in such disorders as cancer, Alzheimer’s disease and Parkinson’s. They also describe the surprising effect of”epigenetic pollution,” environmental contaminants which aren’t detected by standard testing and that can cause serious health issues.
Like all living systems, cells are constantly changing and grow, divide and die. All cells require a constant supply of energy, and this procedure is initiated by a process called”mimetic induction”. Through natural selection, positive mutations accumulate over generations, and if they get together, these cells form a sort of cellular memory, or methylation state. This methylation state is passed on between generations and decides how cells in one family will behave in response to environmental challenges and how those cells will respond when similar challenges arise in another household member.
When methylation is induced in a cell, the result may be a whole gamut of changes on the cell surface and in the biochemical pathways within the cell. This results in alterations in gene function and a corresponding reaction on the body. There are a number of ways in which Epigenetic’s Science presents the science of Epigenetics. For example, each chapter includes an informative section addressing one of the most common Epigenetic changes which exist in all of us: puberty. The chapters comprise;”Growthal Sensitivity,””Mutations in Birth,”” hormonal changes,””perinatal development,””adolescent-onset diabetes,” and”nutrition.” I enjoyed each of them and found them to be very interesting and educational.
As you know, during adolescence, the body increases its production of estrogen (in anticipation of future pregnancy), and then, produces DHT (which stands for”dihydrotestosterone”). DHT subsequently binds to the hair follicles, which makes it difficult for nutrients to reach the roots. This causes baldness in a condition known as”male pattern baldness.” Interestingly, this isn’t the only cause of hair loss, since there are other genetic and environmental factors that contribute to hair loss. Epigenetic science goes a step further and suggests that these other causes of hair loss may also be affected by methylation, so future research might shed more light on Epigenetic’s Science.
The next topic that Epigenetic’s Science touches on is the impact that diet has on the body. Specifically, Epigenetic’s Science goes into detail concerning the impact that diet has on mice, worms, and other organisms. To begin with, one interesting finding was that when the worm C. elegans was given a high fat diet, it became diabetic and obese. Interestingly, the lab animals also lost muscle mass, which is indicative of insulin resistance. In another experiment, the lab animals were put on a particular type of diet where they only received food that contained carbohydrates; they lost body weight fairly rapidly.
In order to understand what is going on here, you must have a look at the Epigenetic’s Science methodology. Fundamentally, they are growing yeast in laboratory cultures and watching what happens. After the yeast grows to a certain point, it is going to replicate and thus create a new production of yeast cells. In cases like this, the generation of cells has been used to study insulin resistance, something that we humans have.
Of course, there are other Epigenetic’s Science techniques that they use, including gene regulation and the analysis of cancerous tumors. In fact, they have recently launched a successful clinical trial where they are attempting to treat Alzheimer’s disease in mice. As exciting as that may sound, it is not your everyday normal cancer therapy. This study shows they are able to manipulate and regulate cells and stop the growth of cancerous tumors.
In addition to diabetes, Epigenetic’s Science can be used for other kinds of diseases and conditions, such as Parkinson’s, arthritis, Multiple Sclerosis, and even cancer. Needless to say, these studies are very small so we do not have much of a sense of what they will mean for human health. Still, it is an exciting and very promising prospect. Just think, one day you could have the ability to grow your own cells for immune system support and energy production; essentially creating your own drug factory!