Epigenetic’s Science is written by award winning writer, Raoul Pedretta. Great bye, genetically encoded genes… the first book in the exciting new field of epigenetic biology for general readers. The surging new science of epigenetic genetics provides a veritable cornucopia of fresh insights into our own bodies and minds – some unsettling, some reassuring. The premise of Epigenetic’s Science is the fact that environmental exposures can have long lasting effects on cellular function. Some of these effects are not very easy to reverse and the authors describe how”epigenetic inheritance” can lead to such illnesses as cancer, Alzheimer’s disease and Parkinson’s. They also describe the surprising effect of”epigenetic pollution,” environmental contaminants which are not detected by standard testing and that could cause serious health problems.
Like all living systems, cells are constantly changing and grow, divide and die. All cells require a continuous supply of energy, and this procedure is initiated by a process referred to as”mimetic induction”. Through natural selection, favorable mutations accumulate over generations, and if they get together, these cells form a sort of cellular memory, or methylation state. This methylation state is passed between generations and determines how cells in 1 family will act in response to environmental challenges and how those cells will react when similar challenges arise in a different household member.
When methylation is induced in a cell, the result may be a whole gamut of changes on the cell surface and in the biochemical pathways inside the cell. This results in alterations in gene function and a corresponding reaction physically. There are a number of ways in which Epigenetic’s Science presents the science of Epigenetics. By way of example, each chapter includes an informative section addressing one of the most frequent Epigenetic changes which occur in all of us: puberty. The chapters comprise;”Growthal Sensitivity,””Mutations in Birth,”” hormonal changes,””perinatal development,””adolescent-onset diabetes,” and”nutrition.” I enjoyed each of these and found them to be quite interesting and educational.
As you know, during adolescence, the body increases its production of estrogen (in anticipation of future pregnancy), and then, produces DHT (which stands for”dihydrotestosterone”). DHT then binds to the hair follicles, which makes it difficult for nutrients to reach the roots. This causes baldness in men and a condition called”male pattern baldness” Interestingly, this is not the only cause of hair loss, as there are other environmental and genetic factors that contribute to hair loss. Epigenetic science goes a step further and suggests that these other causes of hair loss may also be affected by methylation, so future study may shed even more light on Epigenetic’s Science.
The next topic that Epigenetic’s Science touches on is the impact that diet has on the body. Specifically, Epigenetic’s Science goes into detail about the effect that diet has on mice, worms, and other organisms. To start with, one interesting finding was that when the worm C. elegans has been given a high fat diet, it became obese and diabetic. Interestingly, the laboratory animals also lost muscle mass, which is suggestive of insulin resistance. In another experiment, the laboratory animals were put on a special sort of diet where they only received food which contained carbohydrates; they lost body fat fairly rapidly.
So as to understand what is happening here, you must have a look at the Epigenetic’s Science methodology. Fundamentally, they’re growing yeast in lab cultures and watching what happens. When the yeast grows to a certain point, it is going to replicate and thus create a new generation of yeast cells. In this case, the generation of cells was used to study insulin resistance, something that we humans possess.
Needless to say, there are additional Epigenetic’s Science techniques that they use, such as gene regulation and the study of cancerous tumors. In fact, they have recently launched a successful clinical trial where they are attempting to treat Alzheimer’s disease in mice. As exciting as that may seem, it’s not your regular normal cancer therapy. This study shows they are able to control and regulate cells and stop the growth of cancerous tumors.
In addition to diabetes, Epigenetic’s Science can be used for other types of diseases and ailments, such as Parkinson’s, arthritis, Multiple Sclerosis, and even cancer. Of course, these studies are extremely small so we do not have much of a sense of what they will mean for human health. Still, it is an exciting and very promising prospect. Just think, one day you might have the ability to grow your own cells for immune system support and energy generation; essentially creating your own drug factory!