Epigenetic’s Science is composed by award winning author, Raoul Pedretta. Good bye, genetically encoded genes… the first book in the exciting new field of epigenetic biology for general readers. The surging new science of epigenetic genetics provides a veritable cornucopia of fresh insights into our bodies and minds – some unsettling, some reassuring. The premise of Epigenetic’s Science is the fact that environmental exposures can have long lasting effects on cellular function. Some of these effects are not so easy to reverse and the authors describe how”epigenetic inheritance” can lead to such illnesses as cancer, Alzheimer’s disease and Parkinson’s. They also describe the surprising effect of”epigenetic pollution,” environmental contaminants that are not detected by regular testing and that can cause severe health problems.
Like all living systems, cells are constantly changing and grow, divide and die. All cells require a continuous supply of energy, and this process is initiated by a process called”mimetic induction”. Through natural selection, favorable mutations accumulate over generations, and if they get together, these cells form a sort of cellular memory, or methylation state. This methylation state is passed between generations and determines how cells in one family will act in response to environmental challenges and how those cells will react when similar challenges arise in another family member.
When methylation is induced in a cell, the result can be a whole gamut of changes on the cell surface and in the biochemical pathways inside the cell. This causes alterations in gene function and a corresponding response on the body. There are many ways in which Epigenetic’s Science presents the science of Epigenetics. By way of example, each chapter contains an informative section covering among the most common Epigenetic changes that occur in all of us: puberty. The chapters comprise;”Growthal Sensitivity,””Mutations at Birth,”” hormonal changes,””perinatal development,””adolescent-onset diabetes,” and”nutrition.” I enjoyed each of them and found them to be quite interesting and educational.
As you know, during adolescence, the body increases its production of estrogen (in anticipation of future pregnancy), and then, produces DHT (which stands for”dihydrotestosterone”). DHT then binds to the hair follicles, which makes it difficult for nutrients to reach the roots. This causes baldness in a condition known as”male pattern baldness.” Interestingly, this is not the only cause of hair loss, since there are other genetic and environmental factors that contribute to hair loss. Epigenetic science goes a step further and suggests that these other causes of hair loss may also be affected by methylation, so future research may shed more light on Epigenetic’s Science.
The next topic that Epigenetic’s Science touches on is the impact that diet has on the body. Specifically, Epigenetic’s Science goes into detail concerning the impact that diet has on mice, worms, and other organisms. To begin with, one interesting finding was that when the worm C. elegans was given a high fat diet, it became diabetic and obese. Interestingly, the laboratory animals also lost muscle mass, which is suggestive of insulin resistance. In another experiment, the lab animals were put on a special sort of diet where they just received food which contained carbohydrates; they lost body weight fairly quickly.
In order to understand what’s going on here, you have to have a look at the Epigenetic’s Science methodology. Basically, they are growing yeast in lab cultures and watching what happens. After the yeast grows to a certain point, it is going to replicate and thus create a new generation of yeast cells. In this case, the creation of cells was used to study insulin resistance, something that we humans possess.
Of course, there are other Epigenetic’s Science techniques they use, such as gene regulation and the study of cancerous tumors. In actuality, they’ve recently launched a successful clinical trial in which they’re attempting to treat Alzheimer’s disease in mice. As exciting as that may seem, it’s not your everyday normal cancer therapy. This study shows they are able to control and regulate cells and stop the growth of cancerous tumors.
In addition to diabetes, Epigenetic’s Science may be used for other kinds of diseases and ailments, such as Parkinson’s, arthritis, Multiple Sclerosis, and even cancer. Of course, these studies are very small so we do not have much of a sense of what they will mean for human health. Still, it’s an exciting and very promising prospect. Just think, one day you might be able to grow your own cells for immune system support and energy production; essentially creating your very own drug factory!