Epigenetic’s Science is written by award winning author, Raoul Pedretta. Good bye, genetically encoded genes… the first book in the exciting new field of epigenetic biology for general readers. The surging new science of epigenetic genetics provides a veritable cornucopia of fresh insights into our own bodies and minds – some unsettling, some reassuring. The premise of Epigenetic’s Science is the fact that environmental exposures can have long lasting effects on cellular function. Some of these effects aren’t so easy to reverse and the authors describe how”epigenetic inheritance” can lead to such illnesses as cancer, Alzheimer’s disease and Parkinson’s. They also clarify the surprising effect of”epigenetic pollution,” environmental contaminants which are not detected by standard testing and that could cause severe health issues.
Like all living systems, cells are constantly changing and grow, divide and die. All cells require a constant supply of energy, and this process is initiated by a process called”mimetic induction”. Through natural selection, favorable mutations accumulate over generations, and if they get together, these cells form a sort of cellular memory, or methylation state. This methylation state is passed on between generations and decides how cells in one family will behave in response to environmental challenges and how those cells will respond when similar challenges arise in a different family member.
When methylation is induced in a cell, the result may be a whole gamut of changes on the cell surface and in the biochemical pathways within the cell. This results in alterations in gene function and a corresponding reaction physically. There are many ways in which Epigenetic’s Science presents the science of Epigenetics. For example, each chapter includes an informative section addressing one of the most common Epigenetic changes that occur in all of us: puberty. The chapters include;”Growthal Sensitivity,””Mutations at Birth,”” hormonal changes,””perinatal development,””adolescent-onset diabetes,” and”nutrition.” I enjoyed each of these and found them to be very interesting and educational.
As you know, during adolescence, the body increases its production of estrogen (in anticipation of future pregnancy), and then, produces DHT (which stands for”dihydrotestosterone”). DHT subsequently binds to the hair follicles, which makes it difficult for nutrients to reach the roots. This causes baldness in a condition called”male pattern baldness” Interestingly, this is not the only cause of hair loss, as there are other environmental and genetic factors that contribute to hair loss. Epigenetic science goes a step further and suggests that these other causes of hair loss may also be influenced by methylation, so future research might shed even more light on Epigenetic’s Science.
The next topic that Epigenetic’s Science touches on is the effect that diet has on the body. Specifically, Epigenetic’s Science goes into detail about the effect that diet has on rats, rodents, and other organisms. To begin with, one interesting finding was that when the worm C. elegans was given a high fat diet, it became diabetic and obese. Interestingly, the laboratory animals also lost muscle mass, which is suggestive of insulin resistance. In another experiment, the laboratory animals were put on a special type of diet where they only received food that contained carbohydrates; they lost body weight fairly quickly.
So as to understand what is happening here, you have to take a look at the Epigenetic’s Science methodology. Fundamentally, they are growing yeast in laboratory cultures and watching what happens. After the yeast grows to a certain point, it will replicate and thus create a new production of yeast cells. In cases like this, the creation of cells was used to study insulin resistance, something that we humans possess.
Of course, there are additional Epigenetic’s Science techniques they use, including gene regulation and the study of cancerous tumors. In fact, they have recently launched a successful clinical trial where they are attempting to treat Alzheimer’s disease in mice. As exciting as that may sound, it is not your regular normal cancer treatment. This study shows they are able to control and regulate cells and stop the growth of cancerous tumors.
Besides diabetes, Epigenetic’s Science can be used for other types of diseases and ailments, such as Parkinson’s, arthritis, Multiple Sclerosis, and even cancer. Needless to say, these studies are very small so we don’t have much of a sense of what they will mean for human health. Still, it’s an exciting and very promising prospect. Just think, one day you could be able to grow your own cells for immune system support and energy generation; essentially creating your own drug factory!