Epigenetic’s Science is written by award winning author, Raoul Pedretta. Good bye, genetically encoded genes… the first book in the exciting new field of epigenetic biology for general readers. The surging new science of epigenetic genetics provides a veritable cornucopia of fresh insights into our bodies and minds – some unsettling, some comforting. The assumption of Epigenetic’s Science is the fact that environmental exposures can have long lasting effects on cellular function. Some of these effects aren’t so easy to reverse and the authors describe how”epigenetic inheritance” can lead to such disorders as cancer, Alzheimer’s disease and Parkinson’s. They also describe the surprising effect of”epigenetic pollution,” environmental contaminants that aren’t detected by regular testing and that could cause severe health problems.
Like all living systems, cells are constantly changing and grow, divide and die. All cells need a constant supply of energy, and this procedure is initiated by a process called”mimetic induction”. Through natural selection, positive mutations accumulate over generations, and if they get together, these cells form a type of cellular memory, or methylation state. This methylation state is passed on between generations and determines how cells in 1 family will act in response to environmental challenges and how those cells will respond when similar challenges arise in a different household member.
When methylation is induced in a cell, the result may be a whole gamut of changes on the cell surface and in the biochemical pathways inside the cell. This causes alterations in gene function and a corresponding response physically. There are a number of ways that Epigenetic’s Science presents the science of Epigenetics. For example, each chapter includes an informative section addressing one of the most frequent Epigenetic changes that exist in all people: puberty. The chapters include;”Growthal Sensitivity,””Mutations at Birth,”” hormonal changes,””perinatal development,””adolescent-onset diabetes,” and”nutrition.” I enjoyed each of these and found them to be very interesting and educational.
As you know, during adolescence, the body increases its production of estrogen (in anticipation of future pregnancy), and then, produces DHT (which stands for”dihydrotestosterone”). DHT then binds to the hair follicles, which makes it difficult for nutrients to reach the roots. This causes baldness in a condition known as”male pattern baldness.” Interestingly, this isn’t the only cause of hair loss, since there are other environmental and genetic factors that contribute to hair loss. Epigenetic science goes a step further and suggests that these other causes of hair loss may also be affected by methylation, so future research may shed more light on Epigenetic’s Science.
The next topic that Epigenetic’s Science touches on is the impact that diet has on the body. Specifically, Epigenetic’s Science goes into detail about the impact that diet has on rats, rodents, and other organisms. To begin with, one interesting finding was that when the worm C. elegans has been given a high fat diet, it became diabetic and obese. Interestingly, the laboratory animals also lost muscle mass, which is indicative of insulin resistance. In another experiment, the laboratory animals were put on a special sort of diet where they only received food that contained carbohydrates; they lost body weight fairly quickly.
In order to understand what is going on here, you must have a look at the Epigenetic’s Science methodology. Fundamentally, they’re growing yeast in lab cultures and watching what happens. After the yeast grows to a certain point, it is going to replicate and thus create a new production of yeast cells. In cases like this, the generation of cells has been used to study insulin resistance, something that we humans have.
Of course, there are additional Epigenetic’s Science techniques they use, such as gene regulation and the analysis of cancerous tumors. In fact, they have recently established a successful clinical trial where they are attempting to treat Alzheimer’s disease in mice. As exciting as that may seem, it is not your regular normal cancer treatment. This study shows they are able to manipulate and regulate cells and halt the growth of cancerous tumors.
Besides diabetes, Epigenetic’s Science can be used for other kinds of diseases and conditions, such as Parkinson’s, arthritis, Multiple Sclerosis, and even cancer. Of course, these studies are extremely small so we don’t have much of a sense of what they will mean for human health. Still, it’s an exciting and very promising prospect. Just think, one day you could be able to grow your own cells for immune system support and energy production; essentially creating your very own drug factory!