Epigenetic’s Science is written by award winning author, Raoul Pedretta. Good bye, genetically encoded genes… the first book in the exciting new field of epigenetic biology for general readers. The surging new science of epigenetic genetics offers a veritable cornucopia of fresh insights into our own bodies and minds – some unsettling, some comforting. The assumption of Epigenetic’s Science is the fact that environmental exposures can have long lasting effects on cellular function. Some of these effects aren’t very easy to reverse and the authors describe how”epigenetic inheritance” can result in such disorders as cancer, Alzheimer’s disease and Parkinson’s. They also clarify the surprising effect of”epigenetic pollution,” environmental contaminants that aren’t detected by regular testing and that can cause serious health problems.
Like all living systems, cells are constantly changing and grow, divide and die. All cells require a constant supply of energy, and this process is initiated by a process referred to as”mimetic induction”. Through natural selection, favorable mutations accumulate over generations, and when they get together, these cells form a type of cellular memory, or methylation state. This methylation state is passed between generations and determines how cells in one family will behave in response to environmental challenges and how those cells will respond when similar challenges arise in a different household member.
When methylation is induced in a cell, the result may be a whole gamut of changes on the cell surface and in the biochemical pathways within the cell. This causes alterations in gene function and a corresponding reaction physically. There are many ways that Epigenetic’s Science presents the science of Epigenetics. For instance, each chapter includes an informative section covering among the most common Epigenetic changes which exist in all of us: puberty. The chapters include;”Growthal Sensitivity,””Mutations at Birth,”” hormonal changes,””perinatal development,””adolescent-onset diabetes,” and”nutrition.” I enjoyed each of these and found them to be quite interesting and educational.
As you know, during adolescence, the body increases its production of estrogen (in anticipation of future pregnancy), and then, produces DHT (which stands for”dihydrotestosterone”). DHT subsequently binds to the hair follicles, which makes it difficult for nutrients to reach the roots. This causes baldness in a condition known as”male pattern baldness” Interestingly, this is not the only cause of hair loss, since there are other genetic and environmental factors that contribute to hair loss. Epigenetic science goes a step further and suggests that these other causes of hair loss may also be affected by methylation, so future study might shed more light on Epigenetic’s Science.
The next topic that Epigenetic’s Science touches on is the effect that diet has on the body. Specifically, Epigenetic’s Science goes into detail about the effect that diet has on rats, rodents, and other organisms. To start with, one interesting finding was that when the worm C. elegans was given a high fat diet, it became diabetic and obese. Interestingly, the laboratory animals also lost muscle mass, which is suggestive of insulin resistance. In another experiment, the lab animals were put on a special sort of diet where they just received food that contained carbohydrates; they lost body weight fairly rapidly.
So as to understand what is going on here, you have to have a look at the Epigenetic’s Science methodology. Basically, they’re growing yeast in lab cultures and watching what happens. When the yeast grows to a certain point, it will replicate and thus create a new generation of yeast cells. In cases like this, the creation of cells has been used to study insulin resistance, something that we humans have.
Of course, there are other Epigenetic’s Science techniques that they use, such as gene regulation and the analysis of cancerous tumors. In actuality, they’ve recently launched a successful clinical trial in which they are trying to treat Alzheimer’s disease in mice. As exciting as that may seem, it is not your everyday normal cancer treatment. This study shows they are able to control and regulate cells and halt the growth of cancerous tumors.
Besides diabetes, Epigenetic’s Science can be used for other types of diseases and conditions, such as Parkinson’s, arthritis, Multiple Sclerosis, and even cancer. Needless to say, these studies are very small so we do not have much of a sense of what they will mean for human health. Still, it is an exciting and very promising prospect. Just think, one day you might have the ability to grow your own cells for immune system support and energy generation; essentially creating your very own drug factory!