Epigenetic’s Science is composed by award winning writer, Raoul Pedretta. Good bye, genetically encoded genes… the first book in the exciting new field of epigenetic biology for general readers. The surging new science of epigenetic genetics offers a veritable cornucopia of fresh insights into our own bodies and minds – some unsettling, some comforting. The assumption of Epigenetic’s Science is that environmental exposures can have long lasting effects on cellular function. Some of these effects aren’t so easy to reverse and the authors describe how”epigenetic inheritance” can result in such disorders as cancer, Alzheimer’s disease and Parkinson’s. They also clarify the surprising effect of”epigenetic pollution,” environmental contaminants which aren’t detected by standard testing and that could cause serious health problems.
Like all living systems, cells are constantly changing and grow, divide and die. All cells need a constant supply of energy, and this procedure is initiated by a process called”mimetic induction”. Through natural selection, favorable mutations accumulate over generations, and if they get together, these cells form a sort of cellular memory, or methylation state. This methylation state is passed on between generations and determines how cells in 1 family will behave in response to environmental challenges and how those cells will react when similar challenges arise in another family member.
When methylation is induced in a cell, the result may be a whole gamut of changes on the cell surface and in the biochemical pathways within the cell. This causes alterations in gene function and a corresponding response physically. There are many ways that Epigenetic’s Science presents the science of Epigenetics. For instance, each chapter includes an informative section addressing one of the most common Epigenetic changes which occur in all of us: puberty. The chapters include;”Growthal Sensitivity,””Mutations in Birth,”” hormonal changes,””perinatal development,””adolescent-onset diabetes,” and”nutrition.” I enjoyed each of them and found them to be very interesting and educational.
As you know, during adolescence, the body increases its production of estrogen (in anticipation of future pregnancy), and in turn, produces DHT (which stands for”dihydrotestosterone”). DHT then binds to the hair follicles, which makes it difficult for nutrients to reach the roots. This causes baldness in men and a condition known as”male pattern baldness” Interestingly, this is not the only cause of hair loss, since there are other genetic and environmental factors that contribute to hair loss. Epigenetic science goes a step further and suggests that these other causes of hair loss may also be affected by methylation, so future research might shed even more light on Epigenetic’s Science.
The next topic that Epigenetic’s Science touches on is the impact that diet has on the body. Specifically, Epigenetic’s Science goes into detail about the effect that diet has on rats, rodents, and other organisms. To start with, one interesting finding was that when the worm C. elegans was given a high fat diet, it became diabetic and obese. Interestingly, the lab animals also lost muscle mass, which is suggestive of insulin resistance. In another experiment, the laboratory animals were put on a special sort of diet where they only received food which contained carbohydrates; they lost body weight fairly quickly.
In order to understand what’s happening here, you have to have a look at the Epigenetic’s Science methodology. Basically, they are growing yeast in lab cultures and watching what happens. When the yeast grows to a certain point, it will replicate and thus create a new production of yeast cells. In cases like this, the generation of cells was used to study insulin resistance, something that we humans have.
Of course, there are additional Epigenetic’s Science techniques they use, including gene regulation and the study of cancerous tumors. In fact, they’ve recently launched a successful clinical trial where they are trying to treat Alzheimer’s disease in mice. As exciting as that may sound, it is not your everyday normal cancer treatment. This study shows that they are able to manipulate and regulate cells and stop the growth of cancerous tumors.
Besides diabetes, Epigenetic’s Science may be used for other kinds of diseases and conditions, such as Parkinson’s, arthritis, Multiple Sclerosis, and even cancer. Needless to say, these studies are extremely small so we don’t have much of a sense of what they will mean for human health. Still, it’s an exciting and very promising prospect. Just think, one day you could have the ability to grow your own cells for immune system support and energy production; essentially creating your own drug factory!