Epigenetic’s Science is composed by award winning author, Raoul Pedretta. Good bye, genetically encoded genes… the first book in the exciting new field of epigenetic biology for general readers. The surging new science of epigenetic genetics provides a veritable cornucopia of new insights into our bodies and minds – some unsettling, some comforting. The premise of Epigenetic’s Science is that environmental exposures can have long lasting effects on cellular function. Some of these effects are not very easy to reverse and the authors describe how”epigenetic inheritance” can lead to such disorders as cancer, Alzheimer’s disease and Parkinson’s. They also describe the surprising effect of”epigenetic pollution,” environmental contaminants that aren’t detected by standard testing and that could cause serious health problems.
Like all living systems, cells are constantly changing and grow, divide and die. All cells require a continuous supply of energy, and this procedure is initiated by a process referred to as”mimetic induction”. Through natural selection, positive mutations accumulate over generations, and if they get together, these cells form a sort of cellular memory, or methylation state. This methylation state is passed on between generations and decides how cells in one family will act in response to environmental challenges and how those cells will respond when similar challenges arise in a different family member.
When methylation is induced in a cell, the result can be a whole gamut of changes on the cell surface and in the biochemical pathways within the cell. This causes alterations in gene function and a corresponding reaction physically. There are a number of ways in which Epigenetic’s Science presents the science of Epigenetics. For example, each chapter includes an informative section covering among the most common Epigenetic changes which occur in all of us: puberty. The chapters comprise;”Growthal Sensitivity,””Mutations in Birth,”” hormonal changes,””perinatal development,””adolescent-onset diabetes,” and”nutrition.” I enjoyed each of them and found them to be quite interesting and educational.
As you know, during adolescence, the body increases its production of estrogen (in anticipation of future pregnancy), and then, produces DHT (which stands for”dihydrotestosterone”). DHT subsequently binds to the hair follicles, which makes it difficult for nutrients to reach the roots. This causes baldness in a condition called”male pattern baldness” Interestingly, this isn’t the only cause of hair loss, since there are other environmental and genetic factors that contribute to hair loss. Epigenetic science goes a step further and suggests that these other causes of hair loss may also be affected by methylation, so future research might shed more light on Epigenetic’s Science.
The next topic that Epigenetic’s Science touches on is the effect that diet has on the body. In particular, Epigenetic’s Science goes into detail about the effect that diet has on rats, rodents, and other organisms. To start with, one interesting finding was that when the worm C. elegans was given a high fat diet, it became obese and diabetic. Interestingly, the laboratory animals also lost muscle mass, which is indicative of insulin resistance. In another experiment, the laboratory animals were put on a particular type of diet where they just received food that contained carbohydrates; they lost body weight fairly quickly.
In order to understand what is happening here, you must take a look at the Epigenetic’s Science methodology. Basically, they are growing yeast in lab cultures and watching what happens. After the yeast grows to a certain point, it will replicate and thus create a new production of yeast cells. In this case, the generation of cells has been used to study insulin resistance, something that we humans have.
Needless to say, there are additional Epigenetic’s Science techniques that they use, such as gene regulation and the analysis of cancerous tumors. In actuality, they have recently established a successful clinical trial where they’re trying to treat Alzheimer’s disease in mice. As exciting as that may sound, it is not your regular normal cancer therapy. This study shows that they are able to control and regulate cells and halt the growth of cancerous tumors.
In addition to diabetes, Epigenetic’s Science may be used for other kinds of diseases and conditions, such as Parkinson’s, arthritis, Multiple Sclerosis, and even cancer. Of course, these studies are very small so we don’t have much of a sense of what they will mean for human health. Still, it’s an exciting and very promising prospect. Just think, one day you might have the ability to grow your own cells for immune system support and energy production; essentially creating your own drug factory!