Epigenetic’s Science is written by award winning writer, Raoul Pedretta. Great bye, genetically encoded genes… the first book in the exciting new field of epigenetic biology for general readers. The surging new science of epigenetic genetics provides a veritable cornucopia of fresh insights into our own bodies and minds – some unsettling, some reassuring. The premise of Epigenetic’s Science is the fact that environmental exposures can have long lasting effects on cellular function. Some of these effects aren’t so easy to reverse and the authors describe how”epigenetic inheritance” can result in such disorders as cancer, Alzheimer’s disease and Parkinson’s. They also describe the surprising effect of”epigenetic pollution,” environmental contaminants which aren’t detected by standard testing and that could cause serious health issues.
Like all living systems, cells are constantly changing and grow, divide and die. All cells require a constant supply of energy, and this procedure is initiated by a process called”mimetic induction”. Through natural selection, favorable mutations accumulate over generations, and when they get together, these cells form a sort of cellular memory, or methylation state. This methylation state is passed between generations and determines how cells in one family will behave in response to environmental challenges and how those cells will respond when similar challenges arise in a different family member.
When methylation is induced in a cell, the result can be a whole gamut of changes on the cell surface and in the biochemical pathways within the cell. This causes alterations in gene function and a corresponding response physically. There are a number of ways in which Epigenetic’s Science presents the science of Epigenetics. For instance, each chapter contains an informative section covering among the most frequent Epigenetic changes which exist in all of us: puberty. The chapters include;”Growthal Sensitivity,””Mutations in Birth,”” hormonal changes,””perinatal development,””adolescent-onset diabetes,” and”nutrition.” I enjoyed each of these and found them to be very interesting and educational.
As you know, during adolescence, the body increases its production of estrogen (in anticipation of future pregnancy), and then, produces DHT (which stands for”dihydrotestosterone”). DHT subsequently binds to the hair follicles, which makes it difficult for nutrients to reach the roots. This causes baldness in men and a condition known as”male pattern baldness” Interestingly, this isn’t the only cause of hair loss, as there are other genetic and environmental factors that contribute to hair loss. Epigenetic science goes a step further and suggests that these other causes of hair loss may also be influenced by methylation, so future study may shed more light on Epigenetic’s Science.
The next topic that Epigenetic’s Science touches on is the impact that diet has on the body. In particular, Epigenetic’s Science goes into detail about the impact that diet has on mice, worms, and other organisms. To begin with, one interesting finding was that when the worm C. elegans was given a high fat diet, it became obese and diabetic. Interestingly, the laboratory animals also lost muscle mass, which is suggestive of insulin resistance. In another experiment, the lab animals were put on a special sort of diet where they only received food which contained carbohydrates; they lost body weight fairly rapidly.
So as to understand what is happening here, you must have a look at the Epigenetic’s Science methodology. Fundamentally, they’re growing yeast in laboratory cultures and watching what happens. After the yeast grows to a certain point, it is going to replicate and thus create a new generation of yeast cells. In cases like this, the creation of cells was used to study insulin resistance, something that we humans have.
Needless to say, there are other Epigenetic’s Science techniques that they use, such as gene regulation and the study of cancerous tumors. In actuality, they have recently launched a successful clinical trial where they are attempting to treat Alzheimer’s disease in mice. As exciting as that may sound, it is not your everyday normal cancer treatment. This study shows that they are able to manipulate and regulate cells and halt the growth of cancerous tumors.
In addition to diabetes, Epigenetic’s Science may be used for other kinds of diseases and conditions, such as Parkinson’s, arthritis, Multiple Sclerosis, and even cancer. Needless to say, these studies are extremely small so we don’t have much of a sense of what they will mean for human health. Still, it is an exciting and very promising prospect. Just think, one day you might have the ability to grow your own cells for immune system support and energy production; essentially creating your own drug factory!